Nearly 40% of greenhouse gas (GHG) emissions in Latin America were from agriculture, forestry, and other land use (AFOLU) in 2008, more than double the global fraction of AFOLU emissions. In this article, we investigate the future trajectory of AFOLU GHG emissions in Latin America, with and without efforts to mitigate, using a multi-model comparison approach. We find significant uncertainty in future emissions with and without climate policy. This uncertainty is due to differences in a variety of assumptions including (1) the role of bioenergy, (2) where and how bioenergy is produced, (3) the availability of afforestation options in climate mitigation policy, and (4) N₂O and CH₄ emission intensity. With climate policy, these differences in assumptions can lead to significant variance in mitigation potential, with three models indicating reductions in AFOLU GHG emissions and one model indicating modest increases in AFOLU GHG emissions.