This technical note documents the inventory of non-CO2 greenhouse gas (GHG) and traditional air pollutant emissions for the MIT Emissions Prediction and Policy Analysis model version five (EPPA 5). The non-CO2 GHG species considered include methane (CH4), nitrous oxide (N2O), hydrofluorocarbons (HFCs), perfluorocarbons (PFCs), and sulfur hexafluoride (SF6). Traditional air pollutants include carbon monoxide (CO), sulfur dioxide (SO2), nitrous oxides (NOx), ammonia (NH3), black carbon (BC), organic carbon (OC), and non-methane volatile organic compounds (NMVOCs). In considering non-CO2 GHG data sets, we evaluate bottom-up inventories from the Emissions Database for Global Atmospheric Research version 4.1 (EDGAR v4.1), the “U.S. Environmental Protection Agency Global Non-CO2 Anthropogenic Emissions: 1990-2020” report (EPA 2006), and a recent inventory from the Global Trade Analysis Project (GTAP v7). For traditional air pollutants we consider EDGAR v4.1 and EDGAR-HTAP v1. Since EPPA 5 is also used in connection with the MIT Integrated Global System Model (IGSM) to study environmental effects, good agreement with measured GHG concentrations is crucial and we compare bottom-up and top-down estimates to gauge for consistency. We conclude that the EDGAR v4.1 inventory is best suited for benchmarking non-CO2 GHGs in EPPA 5 due to good disaggregation between economic sectors and species, and because it provides the closest fit with top-down estimates.